PHARMACOLOGY OF LSD
When ingested into the human body, LSD acts as a 5-HT (serotonin) receptor activator, while also dramatically increasing serotonin levels in the brain by deactivating systems that regulate serotonin levels.
Of the 15 different serotonin receptors in the brain, ACID mostly prefers the 2A subtype (5-HT2A). The 5-HT2A receptor is involved in cognitive processes in the prefrontal cortex. This is an important point, for this is where many of LSD’s benefits come from: its involvement in the prefrontal cortex.
The prefrontal cortex is thought to be active in planning complex cognitive behavior, personality expression, decision-making, and moderating social behavior. It also plays a key role in a human’s ability to process information from all other brain systems, and make goal-directed decisions as a result.
Recently, researchers at The Beckley Foundation began to investigate the specific effects of LSD on the brain. The research is led by a group of neuroscientists at the Imperial College London. They raised money for the research through a crowd-funded campaign.
Beckley’s latest study involved giving 20 volunteers a small dose of LSD and then using MRI and MEG imaging to show how it affects brain processes.
The researchers believe Acid may reduce blood flow to the control centers of the brain and thus dampening their activity, which ultimately enhances brain connectivity. It’s thought that this increase in brain connectivity, or ‘entropy’, gives rise to the creative and unique thought patterns associated with the psychedelic experience.